Mansor, Azelia
(2017)
Comparison of the effectiveness between kataria and paedfusor models of target controlled infusion (TCI) during anaesthesia in elective paediatric surgery.
Masters thesis, Universiti Sains Malaysia.
Abstract
Background: Kataria and Paedfusor are two validated target controlled infusion (TCI)
models for propofol in paediatric population. The aim of this study was to compare the
effectiveness of these two different TCI models for propofol in paediatric age group
during elective surgery.
Methods: 38 patients, aged 3-12 year-old, classified under ASA I and II, who
underwent elective surgery under general anaesthesia, were randomised into two
groups; Group Kataria (n=19) and Group Paedfusor (n=19). All patients received 1
mcg/kg loading dose of intravenous (IV) remifentanil over 1 minute 15 seconds and
followed with infusion at 0.1 to 1 mcg/kg/min. Then, both groups were induced at
plasma concentration (Cpt) propofol of 6 mcg/ml using respective model and
maintained with Cpt between 3 to 6 mcg/ml guided by bispectral index (BIS) between
40-60. Remifentanil was maintained between 0.1 to 1 mcg/kg/min. Success rate of
induction, induction time, recovery time and plasma concentration (Cp) at recovery
were recorded for statistical analysis.Results: Both groups were successfully induced with propofol Cpt of 6mcg/ml. There
were no significant difference in induction and recovery time between these two groups.
The plasma concentration at recovery in Kataria group was significantly lower than
Paedfusor group [1.48 (0.11) mcg/ml vs 1.59 (0.14) mcg/ml, p=0.01].
Conclusion: TCI propofol for paediatric patients using Kataria and Paedfusor models
were equally effective in success rate of induction, induction time and recovery time.
Only plasma concentration at recovery was lower in Kataria group.
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