Larmie, E.T.
(1995)
Erythrocyte sodium fluxes; intracellular . magnesium
calcium and serum electrolytes in diabetes with pregnancy
induce: hyi3ertension.
Erythrocyte sodium fluxes; intracellular . magnesium calcium and serum electrolytes in diabetes with pregnancy induce: hyi3ertension.
(Submitted)
Abstract
Serum concentrations of sodium, potassium, ionised calcium, toted calcium,
magnesium and erythrocyte sodium efflux rate constants were deternuned
I
spectrophotometricall~ and With 22 Na respectively in normotensive pre~nant
i women (NP), normotersive pregnant womeh With diabetes m~llitus (Ofj), wotnen
with diabetes msllitys and ~regn~ncy-itlduced hypertehsioh (DP-f:'IH) and
women With pregnane 'nduc~J hyp~rtensioh (Nf:»-PIH) ~uring the third trimester
I '
of pregnancy. No sig ificant diheten¢es were evident In: serum total rrlE:t~nesium
I ' I
sodium, potassium, a d lot1ised calci~m or ~rythrocyte hlagtiesium bstween the
four groups. Serum t~tf=!l calcium, hbWSver, was Significantly (p<0.05) lower in
NP-PIH women and ~tH women with diabetes mellitus. The cause for the lower
serum total calcium iJ diabetic ahd hor1-diab9tic PIH women is hot evident but
appears independent ~t the diabetes.
I
!
Erythrocyte mean total• sodium efflUx tate constant was significantly (p < 0.01)
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higher in NP-PIH women. However, the mean ouabain-Insensitive sodium efflux
rate constant was sligHtly higher in OP women. When compared to the other
three groups.
Mean ouabain-sensitive sodium efflux rate constant Was significantly (fl< 0.01; P
< 0.05) higher in NP-fJIH and DP-PIH respectively.
It would appear that while pre9nar1cy-induced hypertension increases the Na+,
K+ -AT pase pump activity, this effect is moderated In the presence of a
preexistin9 diabetes niellitus.
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