Alim, Fadillah
(2004)
Effect of Labisia pumila (Kacip Fatimah) on stress induced changes in leukocyte count and organ weight of albino rats.
Masters thesis, Pusat Pengajian Sains Kesihatan.
Abstract
The extract of Labisia Pumila was screened for its effects on stress induced
changes in leukocyte count and organ weight of albino rats (Wistar strain). The total
leukocyte count in rats was significantly reduced after exposure to noise stress. The
neutrophil percentage was increased significantly but, there was significant decrease
in the percentage of eosinophils and lymphocytes after exposure to noise stress.
Noise stress caused signi~cant increase in the weight of adrenal glands whereas
weight of thymus and spleen were decreased significantly.
Pretreatment of rats with the extract of Labisia Pumila daily ( 1 00 mg/ kg body
weight) for one week, prevented the changes in total leukocyte count, differential
leukocyte count and organ weight induced by acute noise stress. The results of this
study indicate that the plant, Labisia pumila has an antistressor affect against noise.
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