Molecular Mechanisms Of Mitragynine Inhibition On Herg1a/1b Channel

Tay, Yea Lu (2018) Molecular Mechanisms Of Mitragynine Inhibition On Herg1a/1b Channel. PhD thesis, Universiti Sains Malaysia.

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The leaves of Mitragyna speciosa Korth (M. speciosa), commonly known as ketum in Malaysia, have been widely used to treat common illnesses such as intestinal infections, muscle pain, cough, diarrhea, diabetes, hypertension and to improve blood circulation. Nevertheless, there are growing concerns about the safety and abuse or misuse potentials of the plant which exhibits addictive effects. The safety profile of the plant is not fully elucidated. The human ether-a-go-go-related gene 1 (hERG1) encodes the pore-forming subunit underlying cardiac rapidly delayed rectifier potassium current (IKr).

Item Type: Thesis (PhD)
Subjects: R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms
Divisions: Institut Farmaseutikal & Nutraseutikal Malaysia (Malaysian Institute of Pharmaceuticals & Nutraceuticals > Thesis
Depositing User: ASM Ab Shukor Mustapa
Date Deposited: 18 Apr 2019 06:52
Last Modified: 18 Apr 2019 06:52

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