Phytochemical Screening and Cytotoxic Effects of Crude Extracts of Pereskia Bleo Leaves

Salleh, Siti Farhanah Mohd and Ismail, Norzila and Ibrahim, Wan Suriyani Wan and Ismail, Tuan Nadrah Naim Tuan (2020) Phytochemical Screening and Cytotoxic Effects of Crude Extracts of Pereskia Bleo Leaves. Journal of Herbs, Spices and Medicinal Plants. ISSN 1540-3580 (Submitted)

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The phytocompounds in crude solvent extracts of Pereskia bleo leaves were identified and their cytotoxic effects on cancer cell lines were determined. Crude extracts were obtained via maceration and subjected to GCMS analysis. Then, each extract was incubated with HeLa, MDA-MB-231, SW480, and NIH/3T3 cell lines for 72 h. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was done to determine IC50 values of each extract. Terpenoids, sterols, alkaloids, fatty acids and phenolic compounds were identified from the crude extracts of P. bleo leaves. Other compounds identified were γ-sitosterol, β-tocopherol, and γ-tocopherol. The ethyl acetate extract had potent cytotoxic effect against HeLa and MDA-MB-231 cancer cells as noted by the lowest IC50 values

Item Type: Article
Uncontrolled Keywords: GCMS; phytocompounds; antiproliferative; anti-cancer; maceration
Subjects: R Medicine > RC Internal medicine > RC254-282 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Perubatan (School of Medical Sciences) > Article
Zoom Profil Pakar (Expert Profile) > Norzila Ismail (Medical Sciences)
Depositing User: Administrator Automasi
Date Deposited: 16 Apr 2019 03:16
Last Modified: 28 Feb 2020 07:52

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