Keloid Scarring: Understanding the Genetic Basis, Advances, and Prospects

Halim, Ahmad Sukari and Emami, Azadeh and Salahshourifar, Iman and Kannan, Thirumulu Ponnuraj (2012) Keloid Scarring: Understanding the Genetic Basis, Advances, and Prospects. Archives of Plastic Surgery, 39 (3). pp. 184-189. ISSN 2234-6163

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Keloid disease is a fibroproliferative dermal tumor with an unknown etiology that occurs after a skin injury in genetically susceptible individuals. Increased familial aggregation, a higher prevalence in certain races, parallelism in identical twins, and alteration in gene expression all favor a remarkable genetic contribution to keloid pathology. It seems that the environment triggers the disease in genetically susceptible individuals. Several genes have been implicated in the etiology of keloid disease, but no single gene mutation has thus far been found to be responsible. Therefore, a combination of methods such as association, gene-gene interaction, epigenetics, linkage, gene expression, and protein analysis should be applied to determine keloid etiology.

Item Type: Article
Uncontrolled Keywords: Keloid, Skin diseases, Genetics, Environmental exposure
Subjects: R Medicine > RK Dentistry > RK1-715 Dentistry
Divisions: Institut Perubatan & Pergigian Termaju (Advanced Medical & Dental Institute (AMDI)) > Article
Zoom Profil Pakar (Expert Profile) > Kannan Thirumulu Ponnuraj (Dental Sciences)
Depositing User: Administrator Automasi
Date Deposited: 01 Apr 2019 04:58
Last Modified: 01 Apr 2019 04:58

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