Rub, Mohammed Said Saleh Abual
(2011)
Harmony search algorithms for ab initio protein tertiary structure prediction.
PhD thesis, Universiti Sains Malaysia.
Abstract
Meramal struktur tertier protein daripada jujukan linear struktur-struktur tersebut adalah suatu cabaran besar dalam bidang biologi. Tesis ini berkisar tentang ramalan struktur tertier protein ab initio. Algoritma Gelintar Harmoni (HSA) disesuaikan untuk ramalan struktur tertier protein di mana keseluruhan proses dimodelkan sebagai pengoptimunan permasalahan. HAS telah pun memperolehi penyelesaian-penyelesaian yang layak tetapi tidak sehebat yang dilaporkan di dalam penulisan.
Predicting the tertiary structure of proteins from their linear sequence is really a big challenge in biology. This thesis considers the ab initio protein tertiary structure prediction. The Harmony Search Algorithm (HSA) has been adapted for the protein structure prediction by modeling the problem as an optimization problem. HSA has obtained feasible solutions but not as magnificent as those reported in the literature.
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