Alwan, Mohand R.
(2009)
The Effects Of Selenium And Tocotrienol
Supplementation On The Muscle Contractile Properties,
Fatigue, Emg And Antioxidant Status Of Gastrocnemius
Muscle Of Trained And Untrained Rats.
Masters thesis, Universiti Sains Malaysia.
Abstract
Exercise induces radical-mediated oxidative damage of skeletal muscle
membranes which has been implicated in the fatigue process. Selenium (S) is an
important component of cellular selenocompounds and is an integral component of
glutathione Peroxidase (GPx), which catalyze the reduction of harmful peroxides.
Tocotrienol (T) is a major chain breaking antioxidant that has been shown to reduce
contraction mediated oxidative damage. We hypothesized that S and T supplementation
would positively affect muscle contractile function and increase antioxidant enzymes
activities during exercise. To test this postulate, were used sixty-four male Wistar-Kyoto
rats at weight between 300-350g randomized into eight groups with eight rats per group
rats these sample size was calculated using PS software based on comparing two
means of superoxide dismutase (SOD).
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