Preparation and characterization of collagen grafted poly(dimethyl siloxane) modified films for skin substitute applications.

Darvishi, Seyed Mahmood Rezaei (2011) Preparation and characterization of collagen grafted poly(dimethyl siloxane) modified films for skin substitute applications. PhD thesis, Universiti Sains Malaysia.

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Abstract

Poli(dimetil siloxana) (PDMS) filem yang berpusat diubah dengan menggunakan hidrogel dan kolagen untuk menghasilkan pelbagai jenis pengganti kulit. PHEMA (poli(hidroksietil metakrilat)) dan PAA (poli(asid akrilik)) digunakan melalui kaedah jujukan IPN (interpenetrating polymer networks) dan kaedah campuran bagi menghasilkan suatu kumpulan fungsi yang sesuai untuk menempatkan kologen pada lapisan luar PDMS, dalam usaha meningkatkan kebioserasian mereka. Kolagen (jenis I) dipautkan secara kovalen pada saput yang telah diubah suai dengan menggunakan kopel agen untuk mengaktifkan kumpulan hidroksil pada PHEMA dan karboksil pada PAA. Poly(dimethyl siloxane) (PDMS) based films were modified using hydrogels and collagen to produce different types of skin substitute. Poly(hydroxyethyl methacrylate) (PHEMA) and poly(acrylic acid)(PAA) were used via sequential method of interpenetrating polymer networks (IPNs) and blending methods to create suitable functional groups to immobilize collagen in outer layer of PDMS in order to enhance their biocompatibility. Collagen (type I) was covalently linked onto the modified films via coupling agent to activate the hydroxyl groups of PHEMA and the carboxylic groups of PAA.

Item Type:	Thesis (PhD)
Subjects:	T Technology > TN Mining Engineering. Metallurgy > TN1-997 Mining engineering. Metallurgy
Divisions:	Kampus Kejuruteraan (Engineering Campus) > Pusat Pengajian Kejuruteraan Bahan & Sumber Mineral (School of Material & Mineral Resource Engineering) > Thesis
Depositing User:	Mr Erwan Roslan
Date Deposited:	26 Nov 2018 03:43
Last Modified:	26 Nov 2018 03:43
URI:	http://eprints.usm.my/id/eprint/43007

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