Zainal, Nor Ain and Shukor, Syamsul Rizal Abd. and Razak, Khairunisak Abdul
(2015)
Applying the Taguchi Method to Optimise the Size of Silica Nanoparticles Entrapped with Rifampicin for a Drug Delivery System.
Journal of Engineering Science and Technology, 11.
pp. 9-16.
ISSN 1823-4690
Abstract
The aim of this study was to optimise the experimental conditions for the
synthesis of silica nanoparticles. In achieving this, the amount of butanol, the amount of
surfactant, the amount of silica precursor, the synthesis temperature and the agitation
speed were optimised by applying the Taguchi orthogonal arrays method. The optimal
synthesis conditions for silica nanoparticle production were a temperature of 50°C, 6 ml
butanol, 7 ml Tween 80, 3 ml trimethoxyvinylsilane (TMVS), and an agitation speed of
320 rpm. The nanoparticle size was characterised to optimise the synthesis conditions
and determined to be smaller than 100 nm using a Malvern Zetasizer Nano ZS and a
transmission electron microscope (TEM).
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