Leong , Sim Siong and Azudin, Nurhazwani Yusoff and Shukor, Syamsul Rizal Abd
(2014)
Process Modelling of Isoamyl Acetate Synthesis Catalysed by Lipase from Candida antarctica in a Solvent-free System.
Journal of Engineering Science and Technology, 10.
pp. 59-71.
ISSN 1823-4690
Abstract
The objective of this work is to propose a reaction mechanism and develop a
model for the synthesis of isoamyl acetate from isoamyl alcohol and acetate anhydride by
using lipase from Candida antarctica in a solvent-free system. Ping-Pong Bi-Bi reaction
mechanism with acetic anhydride and acetic acid inhibition is found to be the mechanism
which is able to describe this reaction. Unknown parameters of the model developed are
obtained by minimising deviation of model prediction from experimental result and it is
performed by the Solver Tool in Microsoft Excel. The model prediction is found to match
the experimental data quite well (average percentage error = 8.08%)
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