Genotoxicity study of sea coral used as bone replacement material

Hamid, Suzina Sheikh Ab and Samsudin, Ab. Rani and Omar, Nor Shamsuria and Ahmad, Azlina Genotoxicity study of sea coral used as bone replacement material. In: Genotoxicity study of sea coral used as bone replacement material. (Submitted)

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Most of the methods available today to detect carcinogens and mutagens are based upon the principle that genotoxicity/mutagenicity may serve as an indicator of carcinogenic potential.This in vitro study was made to evaluate the genotoxicity characteristic of coral of Porites sp. produced by the National Tissue Bank, Universiti Sains Malaysia (USM), by using the Bacterial Reverse Mutation Assay test or Ames test.The Bacterial Reverse Mutation Assay of the coral material was performed on Salmonella typhimurium strains TA98, TAIOO, TA1535, TA1537 and Escherichia coli strain WP2 uvr A using the preincubation method in the presence and absence of an exogenous metabolic activation system. The results showed the numbers of revertant colonies of all strains which -were treated with the test substance were less than twice that of each negative control with and without S9 Mix.In conclusion the results of the tests showed that the coral material was considered to have no reverse mutagenic potential under the present test condition.

Item Type: Conference or Workshop Item (Paper)
Uncontrolled Keywords: Coral,genotoxicity,mutagenicity,ames test
Subjects: R Medicine > R Medicine (General) > R5-920 Medicine (General)
Divisions: Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Perubatan (School of Medical Sciences) > Conference or Workshop Item
Depositing User: Mr Abdul Hadi Mohammad
Date Deposited: 23 Mar 2020 05:05
Last Modified: 23 Mar 2020 05:05

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