A study on the protective effects of calcium channel blockers against anoxic brain damage

Sunil, Gurtu and S.B, Acharya and H. A., Nadiger and Mohd, Shakil Siddiqui (1997) A study on the protective effects of calcium channel blockers against anoxic brain damage. In: IRPA Short Term Grant, 1st February, 1997, -.

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Introduction It is now widely accepted that a rapid neuronal influx of Ca2+ following cerebral ischaemia! hypoxia is intimately connected with the cascade of events- including activation of enzymes which give rise to the production of reactive oxygen species and nitric oxide, thereby leading to free-radical induced damage -which reseult in neuronal injury and death. It is also known that a burst of free radical generation I occurs during re-oxygenation of the tissues following a period,ofischaernialhypoxia as also a prolonged purturbation of the membrane functions continues after the perfusion/oxygenation has been restored, which leads to continued accumulnnon of calcium intracellularly ; resulting ultimately in delayed damage and death of the neurone. Estimation of lipid peroxidation products proviqes a reliable estimate of free radical induced damage to tissues, and has been widely used for this purpose.

Item Type: Conference or Workshop Item (Paper)
Uncontrolled Keywords: Neuroscience
Subjects: R Medicine > R Medicine (General)
Divisions: Kampus Kesihatan (Health Campus) > Pusat Perkhidmatan & Penyelidikan Neurosains (Center for Neuroscience Services & Research (P3Neuro))
Depositing User: Mr Abdul Hadi Mohammad
Date Deposited: 20 Mar 2020 04:33
Last Modified: 20 Mar 2020 04:33
URI: http://eprints.usm.my/id/eprint/42325

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