Sunil, Gurtu and S.B, Acharya and H. A., Nadiger and Mohd, Shakil Siddiqui
(1997)
A study on the protective effects of calcium channel blockers against anoxic brain damage.
In: IRPA Short Term Grant, 1st February, 1997, -.
Abstract
Introduction
It is now widely accepted that a rapid neuronal influx of Ca2+ following cerebral ischaemia!
hypoxia is intimately connected with the cascade of events- including activation of enzymes which give
rise to the production of reactive oxygen species and nitric oxide, thereby leading to free-radical induced
damage -which reseult in neuronal injury and death. It is also known that a burst of free radical generation
I
occurs during re-oxygenation of the tissues following a period,ofischaernialhypoxia as also a prolonged
purturbation of the membrane functions continues after the perfusion/oxygenation has been restored, which
leads to continued accumulnnon of calcium intracellularly ; resulting ultimately in delayed damage and death
of the neurone.
Estimation of lipid peroxidation products proviqes a reliable estimate of free radical induced damage to
tissues, and has been widely used for this purpose.
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