Genetic Study Of Pocket A And B Domain Of RB1 Gene Among Malaysian Children With Retinoblastoma

Hanafi, Hanani Ahmad Yusof (2009) Genetic Study Of Pocket A And B Domain Of RB1 Gene Among Malaysian Children With Retinoblastoma. Masters thesis, Universiti Sains Malaysia.

Preview

PDF Download (481kB) | Preview

Abstract

Retinoblastoma (RB) is the most common intraocular tumor mainly affecting children under four years of age, with a prevalence of 1 in 15 000 to 20 000 live births. Retinoblastoma is divided into hereditary and non-hereditary types. The development of this malignancy requires both alleles of the tumor suppressor gene RB1 to be knockedout. Recent studies found mutation occurred more frequently in the pocket A and B domain of RB1 gene. The present study was undertaken to identify the mutation in the pocket A and B domain of RB1 gene among retinoblastoma patients in Malaysia, and the association of the mutation to the laterality and stage of the tumor.

Item Type:	Thesis (Masters)
Subjects:	R Medicine > R Medicine (General) > R5-920 Medicine (General)
Divisions:	Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Perubatan (School of Medical Sciences) > Thesis
Depositing User:	ASM Ab Shukor Mustapa
Date Deposited:	12 Sep 2018 07:06
Last Modified:	12 Apr 2019 05:26
URI:	http://eprints.usm.my/id/eprint/41836

Actions (login required)

View Item