Ling, Bong Hoi
(2016)
Controlled trial of oral channa striatus extract and glucosamine sulphate among primary knee osteoarthritis patients.
Masters thesis, Universiti Sains Malaysia.
Abstract
Background
Knee osteoarthritis is the commonest form of arthritis worldwide with significant
impact on the health-related quality of life. Complementary and alternative medicine
use in osteoarthritis is gaining popularity. Channa striatus, an indigenous fresh water
fish in Malaysia is well-known for its nutritional and medicinal value in traditional
medicine. The current evidences support its therapeutic potential in treating primary
knee osteoarthritis patients.
Objectives
The aim of the study was to compare the effectiveness of oral Channa striatus
extract and Glucosamine sulphate in improving knee symptoms and physical
function, as well as in rescue analgesic consumption among primary knee
osteoarthritis patients.
Methods
Seventy eight patients with primary knee osteoarthritis were enrolled into this doubleblind
randomized controlled trial and assigned to receive either Channa striatus 500
mg/day (n = 39) or Glucosamine sulphate 1500 mg/ day (n = 39) for six months. The
efficacy outcome measures were Western Ontario and Mc Master Osteoarthritis
Index WOMAC index for pain, stiffness and physical function, Visual Analogue Scalefor pain during movement and Analgesic score for rescue analgesia consumption.
These outcomes measures were assessed using an intention-to-treat analysis. All
patients were evaluated at baseline, 3 and 6 months post randomization.
Results
All the baseline characteristics were comparable between Channa striatus and
Glucosamine sulphate group. Of 78 patients randomized, 73 completed the study
(Channa striatus, n = 36 and Glucosamine sulphate, n = 37). There were no
statistically significant difference between these two groups in WOMAC index, Visual
Analogue scale and Analgesic score after 6 months of intervention. However, there
were statistically significant improvement in all the domains of WOMAC index based
on time for Channa striatus group from baseline to 3 months up to 6 months.
Although there were improvement observed from 3 to 6 months of treatment, they
were not statistically significant. All the safety profile parameters were normal for
both groups before and after the intervention.
Conclusions
Channa striatus 500 mg/ day is comparable to Glucosamine sulphate 1500 mg/ day
in improving pain, stiffness and physical function in patients with primary knee
osteoarthritis. It could be a new alternative treatment with good safety profile for
medium to long term management of knee osteoarthritis.
Actions (login required)
 |
View Item |
![[img]](http://eprints.usm.my/style/images/fileicons/application_pdf.png)
