Ahmad, Ameilia
(2016)
Optic nerve head and retinal nerve fiber layer analysis in emmetropic Malay children.
Masters thesis, Universiti Sains Malaysia.
Abstract
Background
Optic nerve head (ONH) parameters and retinal nerve fiber layer thickness (RNFLT)
of normal children have been described in previous published reports. None of these
measurements was described among Malay children population using Cirrus spectral
domain optical coherence tomography (SD-OCT). The aim was to report normative
values for ONH parameters and RNFLT in emmetropic Malay children. The possible
correlations between these parameters were also evaluated.
Objectives
To determine the mean of ONH parameters and mean RNFL in emmetropic Malay
children; and to determine correlation between the ONH parameters and RNFL
thickness
Methods
Ninety-five Malay children with no ocular abnormality aged between 7 to 17 years
were recruited into this cross sectional study. It was conducted in Hospital Universiti
Sains Malaysia, Malaysia from January 2014 to December 2015. All children
underwent a complete ocular examination including refraction and axial length
measurement. ONH parameters and RNFLT measurement were performed using
Cirrus SD-OCT machine. One eye of each subject was randomly selected for
analysis. The correlations in between the parameters and influence of age, gender,axial length and spherical equivalent (SE) on measurements were statistically
evaluated.
Results
Ninety-five children were included in the study with 65 females (68.4%) and 30
males (31.6%). Mean age was 10.6 (2.82) years, mean IOP was 14.8 (2.81) mmHg,
mean SE refraction was -0.12 (0.28) diopters and mean axial length was 23.03 (0.76)
mm. Mean (SD) disc area, rim area and cup volume were 2.32 (0.40) mm2, 1.53
(0.33) mm2 and 0.204 (0.16) mm3, respectively. The average cup to disc ratio (SD)
and vertical CDR were 0.55 (0.13) and 0.50 (0.14). Mean (SD) RNFLT for all
patients was 102.08 (11.08) μm. The average, superior and inferior RNFLT showed a
significant positive correlation with the optic disc area. A significant correlation was
also observed between the rim area and average, superior, inferior and nasal RNFLT.
The inferior RNFLT was negatively correlated with average CDR. There was also
significant effect of gender on disc area. There were no significant effects of age,
axial length and SE on the measurements.
Conclusion
This study provides normative data of ONH parameters and RNFLT in emmetropic
Malay children. Emmetropic Malay male had a significantly larger optic disc area.
Increase in RNFLT is associated with significant increase in disc and rim areas.
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