Azman, Khairunnuur Fairuz
(2016)
Effects of Tualang Honey on Memory Performance,
Depressive-like Behaviour, Histological and
Biochemical Changes in Young and Old
Male Rats Exposed to Loud Noise Stress.
PhD thesis, USM.
Abstract
Penuaan dan pendedahan kepada tekanan boleh menyumbang kepada kemerosotan
ingatan dan kemurungan manakala stres oksidatif merupakan salah satu mekanisme
yang mungkin terlibat. Pencarian penambahbaik fungsi kognitif daripada derivatif
produk semulajadi yang mengandungi antioksidan semakin mendapat perhatian.
Oleh itu, kajian ini bertujuan untuk memeriksa kesan penuaan dan tekanan ke atas
prestasi ingatan dan tingkahlaku seperti kemurungan, dan menjelaskan kemungkinan
mekanisme sandaran keberkesanan terapeutik madu Tualang dalam
menambahbaikkan prestasi ingatan dan simptom kemurungan pada tikus jantan muda
dan tua yang terdedah kepada tekanan bunyi bising.
Ageing and stress exposure may lead to memory impairment and depression while
oxidative stress is thought to be one of the underlying mechanisms involved. The
search for cognitive enhancers from natural products derivatives possessing
antioxidants has gained much attention. Thus, this study aimed to examine the effects
of ageing and stress on memory performance and depressive-like behaviour, and to
elucidate the possible mechanisms underlying therapeutic efficacy of Tualang honey
in improving memory performance and depressive symptoms in young and old male
rats exposed to loud noise stress.
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