Shafii, Noorazliyana
(2015)
The effect of oral channa striatus extract administration on total antioxidant status and its relationship with high sensitive c-reactive protein (HSCRP) during wound healing in post lower segment caesarean section women.
Masters thesis, Universiti Sains Malaysia.
Abstract
Introduction: Channa striatus (Haruan) is widely consumed in Malaysia to
promote wound healing which involves three overlapping phases; inflammation,
new tissue formation and tissue remodelling. During inflammatory phase, large
amount of reactive oxygen species (ROS) are produced resulting in severe cell
damage which in turn delays wound healing. CRP has been shown to
significantly increase in response to local inflammation. High sensitive Creactive
protein (hsCRP) detects the same CRP molecule but its lower limit of
detection is lower. C.striatus has been proposed to have antioxidant and antiinflammatory
properties for better healing of the wound.
Objectives: This study was done to determine the level of Total Antioxidant
Status (TAS) in subject receiving C.striatus extract and placebo (maltodextrin)
in post Lower Segment Caesarean Section(LSCS) women. The specific
objectives were to compare the TAS level in C.striatus extract group and
placebo group and to study the relationship between the level of TAS and
hsCRP during wound healing.
Methods: This was a randomized; double blinded, placebo-controlled study
conducted in HUSM. The treatment group consumed 500mg of freeze dried
C.striatus extract daily while the placebo group consumed 500mg of
maltodextrin daily for 6 weeks. Venous bloods were taken from each subject
postoperatively at day 1, day 3, week 2, week 4 and week 6 and were analyzed
for TAS and hsCRP using Selectra E machine. Data analysis was done using
SPSS Version 20.
Result: A total of 73 patients were studied, 39 patients consumed C.striatus
and 34 consumed maltodextrin. The result for TAS, when compared between
both groups showed no significant differences in all the period studied. Within
groups analysis showed that the TAS levels in patients who consumed
C.striatus were all significant (p-value < 0.05) between Day 1 till Week 6 and for
Day 3 with Week 2 and Week 6. The results of hsCRP within groups showed a
significant level between all the periods studied in C.striatus group. The hsCRP
level was highest on day 1 and showed a reducing trend with time. When
compared between the two groups, the hsCRP level showed no significant
difference except for week 6. There was only weak relationship between TAS
and hsCRP on week 4 for C.striatus group.
Conclusion: There was no significant difference in the level of TAS and hsCRP
between C.striatus and placebo group. However, the TAS level showed
increment within group from week 2 onwards which might involve in the
enhancement of wound healing. For hsCRP, there was significant decrease in
these parameters in C.striatus group at week 6 compared to the placebo which
indicates the beneficial effect of C.striatus administration during wound healing
of post LSCS Women. This study showed weak relationship between TAS and hsCRP only on week 4.
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