Quality Of Stored Cord Blood In National Blood Centre Based On Maternal And Neonatal Factors

Azmi, Nor Azhani (2017) Quality Of Stored Cord Blood In National Blood Centre Based On Maternal And Neonatal Factors. Masters thesis, Universiti Sains Malaysia.

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    Abstract

    Latar Belakang: Darah tali pusat (UCB) merupakan sumber alternatif kepada sel tunjang alogenik hematopoetik bagi tujuan pemindahan. Kualiti darah tali pusat yang dikumpulkan bergantung pada kandungan hematopoetiknya yang secara langsung mempengaruhi hasil ‘engraftment’ dan terapeutik. Demi memastikan kualiti darah tali pusat yang dikumpulkan terjamin, kriteria penerimaan darah tali pusat telah diwujudkan di bank tali pusat, Pusat Darah Negara (PDN) yang bersandarkan piawaian antarabangsa. Namun ia telah menyebabkan kadar penyingkiran unit darah tali pusat yang dikumpulkan agak tinggi. Kajian ini bertujuan untuk mengenalpasti hubungkait antara faktor penderma iaitu ibu dan bayi yang boleh mempengaruhi kualiti kandungan hematopoetik darah tali pusat untuk membantu dalam pemilihan penderma dan seterusnya mengurangkan pembaziran. Background: Umbilical cord blood (UCB) is an alternative source of allogeneic haematopoietic stem cells for transplantation. The quality of collected UCB depends on its haematopoietic content which directly influences the engraftment and the therapeutic outcome. To ensure the quality of stored UCB, the acceptance criteria were created at the UCB bank in National Blood Centre (NBC) based on established international standard, which resulted in a high discard rate. This study aims to determine the association of maternal and neonatal factors that could influence the quality of haematopoietic contents of the UCB collections thus guide the choice of donors and reduce wastage.

    Item Type: Thesis (Masters)
    Subjects: R Medicine > RK Dentistry > RK1-715 Dentistry
    Divisions: Institut Perubatan & Pergigian Termaju (Advanced Medical & Dental Institute) > Thesis
    Depositing User: Mr Firdaus Mohamad
    Date Deposited: 25 May 2018 09:57
    Last Modified: 25 May 2018 09:57
    URI: http://eprints.usm.my/id/eprint/40605

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