Abu Bakar, Muhammad Nasri
(2015)
Effect of channa striatus on inflammatory markers as an adjunt treatment in allergic rhinitis-a randomized double-blinded study.
Masters thesis, Universiti Sains Malaysia.
Abstract
Introduction: Channa striatus (snakehead fish) have been shown to have antiinflammatory
and anti-nociceptive properties. This study aimed to discover the effect of its
anti-inflammatory property on the inflammatory process in allergic rhinitis.
Objective(s): To determine the effect of Channa striatus extract on patients’ allergic
rhinitis inflammatory markers, namely eosinophil and interleukin-4 level and their Total
Nasal Symptoms Score.
Methodology: A 6 weeks, randomized double-blinded placebo-controlled trial, parallel
group comparative clinical study. Forty six allergic rhinitis patients were randomized to
receive Channa striatus extract capsules or placebos for 6 weeks. Patients were assessed
clinically at weeks 0, 2 and 6. Blood for serum eosinophil and interleukin-4 were taken at
initial and final visit and the results were compared.
Results: The result showed significant decrement of serum eosinophil level in Channa
striatus group (p<0.05) however the comparative analysis of the mean difference between
two groups was not statistically significant. The result for interleukin-4 level showed no
statistically significant changes in either group. The Total Nasal Symptoms Score reduction
in both group are significant and comparative analysis of the mean difference between two
groups was statistically significant for those with moderate and severe symptoms.
Conclusion: Even though Channa striatus showed nonsignificant additional
immunomodulation effects in laboratory analysis, however its role as an adjunct treatment
in allergic rhinitis did show significant reduction in TNSS for patients with moderate and
severe symptoms.
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