Mat Min, Faridah
(2015)
Evaluation of optic nerve head parameters, retinal nerve fiber layer and macular thickness in metabolic syndrome.
Masters thesis, Universiti Sains Malaysia.
Abstract
TITLE
Evaluation of optic nerve head parameters, retinal nerve fiber layer, and macular
thickness in metabolic syndrome
INTRODUCTION
Metabolic Syndrome (MetS) denotes a common cluster of naturally connected risk
factors including obesity, elevated blood pressure, insulin resistance, dyslipidaemia,
proinflammatory state and prothrombotic state. This systemic risk factor are proved to
have influence on microcirculation and blood flow autoregulation of the optic nerve
head (ONH). The recent availability of retinal imaging such as optical coherence
tomography (OCT) play an important role to differentiate the appearance of optic nerve
head (ONH), retinal nerve fiber layer (RNFL) and macular thickness and therefor can be
used for macular and optic nerve analysis.
OBJECTIVES
This study aim is to evaluate ONH parameters, RNFL and macular thickness using
RTVue-100 Fourier domain OCT in MetS and Non-MetS group among Hospital
Sultanah Nur Zahirah (HSNZ) staffs
METHODOLOGY
A comparative cross sectional study was carried out from Mac 2013 till October 2014 in
Hospital Sultanah Nur Zahirah. A total of 230 eyes was included in this study (one eye
from each of 230 subjects) in which 77 eye from MetS and 156 eye from Non-MetS
group and were compared between this groups. All subjects underwent ophthalmologic
examination including visual acuity, anterior and posterior segment examination. An
assessment of ONH parameters, RNFL and macular thickness in 4 quadrant was
conducted using RTVue-100 OCT.
RESULTS:
The result showed MetS group generally have higher value of ONH parameters as
compared to Non-MetS group with exception of two ONH parameters; disc area and
rim area. Meanwhile for the RNFL parameter thickness generally showed thinner mean
value in MetS group. However there were no statistically significant difference seen
between MetS and Non-MetS for both parameters. Whereas macular parameter
thickness result showed MetS group had thicker mean value compared to Non-MetS
group with exception of inferior hemisphere, superior and inferior quadrant of parafovea
subareas. More specifically, macular thickness were significantly thicker in MetS than
Non-MetS in the temporal quadrant of parafoveal, 304.45(16.61); 293.88(18.82) with p
value <0.001, inferior hemisphere of perifovea 288.10(23.62); 280.09(22.25) with p
value 0.013 and temporal quadrants of perifovea 289.57(21.85); 277.23(21.90) with p
value <0.001.
CONCLUSION:
MetS significantly affect macular thickness at the temporal part of parafovea area,
temporal and inferior hemisphere of perifovea area, but not affect the ONH parameters
and RNFL.
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