Nithianantham, Kuppan and Kwan, Yuet Ping and Yoga Latha, Lachimanan and L. Jothy, Subramanion and Ibrahim, Darah and Yeng, Chen and Chew, Ai Lan and Sasidharan, Sreenivasan (2013) Evaluation of hepatoprotective effect of methanolic extract of Clitoria ternatea (Linn.) flower against acetaminophen-induced liver damage. Asian Pacific Journal of Tropical Disease, 3 (4). pp. 314-319. ISSN 2222-1808
Full text not available from this repository.Abstract
Objective To evaluate the hepatoprotective and antioxidant activity of Clitoria ternatea (C. ternatea) flower extract against acetaminophen-induced liver toxicity. Methods The antioxidant property of C. ternatea flower extract was investigated by employing established in vitro antioxidant assay. The C. ternatea flower extract was studied in this work for its hepatoprotective effect against acetaminophen-induced liver toxicity in mice. Activity was measured by monitoring the levels of aspartate aminotransferase, alanine aminotransferase, billirubin and glutathione with histopathological analysis. Results The amount of total phenolics and flavonoids were estimated to be 105.40±2.47 mg/g gallic acid equivalent and 72.21±0.05 mg/g catechin equivalent respectively. The antioxidant activity of C. ternatea flower extract was 68.9% at a concentration of 1 mg/mL and was also concentration dependant, with an IC50 value of 327.00 μg/mL. The results of acetaminophen-induced liver toxicity experiment showed that mice treated with the extract (200 mg/kg) showed a significant decrease in alanine aminotransferase, aspartate aminotransferase, and bilirubin levels, which were all elevated in the paracetamol group (P<0.05). Meanwhile, the level of glutathione was found to be restored in extract treated animals compared to the groups treated with acetaminophen alone (P<0.05). Therapy of extract also showed its protective effect on histopathological alterations and supported the biochemical finding.
| Item Type: | Article |
|---|---|
| Subjects: | Q Science > QH Natural history > QH1 Natural history (General - Including nature conservation, geographical distribution) R Medicine > R Medicine (General) > R735-854 Medical education. Medical schools. Research |
| Divisions: | Pusat Pengajian Sains Kajihayat (School of Biological Sciences) > Article Zoom Profil Pakar (Expert Profile) > Sasidharan A/L Sreenivasan (Institute for Research In Molecular Medicine) Zoom Profil Pakar (Expert Profile) > Chew Ai Lan (Institute for Research In Molecular Medicine) Zoom Profil Pakar (Expert Profile) > Darah Ibrahim (Biological Sciences) |
| Depositing User: | Mr Noorazilan Noordin |
| Date Deposited: | 19 Feb 2018 09:18 |
| Last Modified: | 19 Feb 2018 09:18 |
| URI: | http://eprints.usm.my/id/eprint/39013 |
Actions (login required)
 |
View Item |
