Pyar, Hassan and Peh, Kok Khiang
(2014)
Enteric coating of granules containing the probiotic
Lactobacillus acidophilus.
Acta Pharmaceutica, 64 (2).
pp. 247-256.
ISSN 1330-0075
Abstract
In the present study, a capsule formulation composed of
enteric coated granules of Lactobacillus acidophilus ATCC
4962 was developed using Eudragit L30D-55 as enteric
polymer. Optimization of the capsule formulation was
achieved with a maximum viable cell count after 2 h of
incubation in acid medium and disintegration time of 1 h
in buffer pH 6.8. The amount of Eudragit L30D-55 in the
capsules correlated with gastric juice resistance. The best
protective qualities against artificial gastric juice were observed
when capsules were prepared from granules composed
of L. acidophilus, corn starch, lactose monohydrate,
polyvinylpyrrolidone and coated with 12.5 % (m/V) of
Eudragit L30D-55. Capsule formulation of L. acidophilus
in edible broth medium suspension serves as a cheap alternative
to the expensive freeze-drying procedure for preparing
L. acidophilus. In addition, the enteric coating using
Eudragit L30D-55 could protect probiotics from the
acidic gastric environment and enhance the bioactivity
of probiotics along with replacement of pathogenic microbes
in human intestine.
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