Nik Yusoff, Nik Syamimi and Mustapha, Zulkarnain and Govindasamy, Chandran and Sirajudeen, K. N. S.
(2013)
Effect of Clonidine (an Antihypertensive Drug) Treatment on Oxidative Stress Markers in the Heart of Spontaneously Hypertensive Rats.
Oxidative Medicine and Cellular Longevity, 2013 (927214).
pp. 1-7.
ISSN 1942-0900
Abstract
Hypertension is a risk factor for several cardiovascular diseases and oxidative stress suggested to be involved in the pathophysiology.
Antihypertensive drug Clonidine action in ameliorating oxidative stress was not well studied. Therefore, this study investigate the
effect of Clonidine on oxidative stress markers and nitric oxide (NO) in SHR and nitric oxide synthase inhibitor, N-nitro-L-arginine
methyl ester (L-NAME) administered SHR. Male rats were divided into four groups [SHR, SHR+Clonidine (SHR-C), SHR+LNAME,
SHR+Clonidine+L-NAME(SHRC+L-NAME)]. Rats (SHRC) were administered with Clonidine (0.5mg kg−1 day−1) from
4 weeks to 28 weeks in drinking water and L-NAME (25mg kg−1 day−1) from 16 weeks to 28 weeks to SHRC+L-NAME. Systolic
blood pressure (SBP) was measured. At the end of 28 weeks, all rats were sacrificed and in their heart homogenate, oxidative stress
parameters and NO was assessed. Clonidine treatment significantly enhanced the total antioxidant status (TAS) (
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