Parkash, Om and Shueb, Rafidah Hanim
(2015)
Diagnosis of Dengue Infection Using Conventional
and Biosensor Based Techniques.
Viruses, 7 (10).
pp. 5410-5427.
ISSN 1999-4915
Abstract
Dengue is an arthropod-borne viral disease caused by four antigenically different
serotypes of dengue virus. This disease is considered as a major public health concern around
the world. Currently, there is no licensed vaccine or antiviral drug available for the prevention
and treatment of dengue disease. Moreover, clinical features of dengue are indistinguishable from
other infectious diseases such as malaria, chikungunya, rickettsia and leptospira. Therefore, prompt
and accurate laboratory diagnostic test is urgently required for disease confirmation and patient
triage. The traditional diagnostic techniques for the dengue virus are viral detection in cell culture,
serological testing, and RNA amplification using reverse transcriptase PCR. This paper discusses
the conventional laboratory methods used for the diagnosis of dengue during the acute and
convalescent phase and highlights the advantages and limitations of these routine laboratory tests.
Subsequently, the biosensor based assays developed using various transducers for the detection of
dengue are also reviewed.
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