Crystal structure of 3-{5-[3-(4-fluorophenyl)-1- isopropyl-1H-indol-2-yl]-1H-pyrazol-1-yl}indolin-2- one ethanol monosolvate

Rahman, Md. Lutfor and Kulkarni, Ajaykumar D. and Mohd. Yusoff, Mashitah and Huey, Chong Kwong and Ching, Kheng Quah (2016) Crystal structure of 3-{5-[3-(4-fluorophenyl)-1- isopropyl-1H-indol-2-yl]-1H-pyrazol-1-yl}indolin-2- one ethanol monosolvate. Acta Crystallographica Section E: Crystallographic Communications, 72. pp. 283-286. ISSN 2056-9890

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Abstract

The title indolin-2-one compound, C28H23FN4O�C2H6O, crystallizes as a 1:1 ethanol solvate. The ethanol molecule is disordered over two positions with refined site occupancies of 0.560 (14) and 0.440 (14). The pyrazole ring makes dihedral angles of 84.16 (10) and 85.33 (9)� with the indolin-2-one and indole rings, respectively, whereas the dihedral angle between indolin-2-one and indole rings is 57.30 (7)�. In the crystal, the components are linked by N—H� � �O and O—H� � �O hydrogen bonds, forming an inversion molecule–solvate 2:2 dimer with R4 4(12) ring motifs. The crystal structure is consolidated by �–� interaction between pairs of inversion-related indolin-2-one rings [interplanar spacing = 3.599 (2) A ° ].

Item Type:	Article
Subjects:	Q Science > QC Physics > QC1-999 Physics Q Science > QD Chemistry > QD1-999 Chemistry
Divisions:	Pusat Pengajian Sains Fizik (School of Physics) > Article Pusat Pengajian Sains Kimia (School of Chemistry) > Article
Depositing User:	Mr Noorazilan Noordin
Date Deposited:	26 Jan 2018 08:58
Last Modified:	26 Jan 2018 08:58
URI:	http://eprints.usm.my/id/eprint/38584

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