Clinacanthus nutans Extracts Are Antioxidant with Antiproliferative Effect on Cultured Human Cancer Cell Lines

Yoke, Keong Yong and Jun, Jie Tan and Soek, Sin Teh and Siau, Hui Mah and Cheng, Gwendoline Lian Ee and Hoe, Siong Chiong and Ahmad, Zuraini (2013) Clinacanthus nutans Extracts Are Antioxidant with Antiproliferative Effect on Cultured Human Cancer Cell Lines. Evidence-Based Complementary and Alternative Medicine, 2013 (462751). pp. 1-8. ISSN 1741-427X

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Abstract

Clinacanthus nutans Lindau leaves (CN) have been used in traditionalmedicine but the therapeutic potential has not been explored for cancer prevention and treatment. Current study aimed to evaluate the antioxidant and antiproliferative effects of CN, extracted in chloroform, methanol, and water, on cancer cell lines. Antioxidant properties of CN were evaluated using DPPH, galvinoxyl, nitric oxide, and hydrogen peroxide based radical scavenging assays, whereas the tumoricidal effect was tested on HepG2, IMR32, NCL-H23, SNU-1, Hela, LS-174T, K562, Raji, and IMR32 cancer cells using MTT assay. Our data showed that CN in chloroform extract was a good antioxidant against DPPH and galvinoxyl radicals, but less effective in negating nitric oxide and hydrogen peroxide radicals. Chloroformextract exerted the highest antiproliferative effect on K-562 (91.28±0.03%) andRaji cell lines (88.97± 1.07%) at 100

Item Type: Article
Subjects: R Medicine > RK Dentistry > RK1-715 Dentistry
Divisions: Institut Perubatan & Pergigian Termaju (Advanced Medical & Dental Institute (AMDI)) > Article
Depositing User: Mr Noorazilan Noordin
Date Deposited: 22 Jan 2018 01:45
Last Modified: 22 Jan 2018 01:45
URI: http://eprints.usm.my/id/eprint/38453

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