Ewe, Seng Ch’ng and Jaafar, Hasnan and Tuan Sharif, Sharifah Emilia
(2011)
Breast Tumor Angiogenesis and Tumor-AssociatedMacrophages:
Histopathologist’s Perspective.
Pathology Research International, 2011 (572706).
pp. 1-13.
ISSN 2090-8091
Abstract
Much progress has been made since the conceptualization of tumor angiogenesis—the induction of growth of new blood vessels
by tumor—as a salient feature of clinically significant primary or metastatic cancers. From a practicing histopathologist’s point
of view, we appraise the application of this concept in breast cancer with particular reference to the evaluation of proangiogenic
factors and the assessment of new microvessels in histopathological examination. Recently, much focus has also been centered on
the active roles played by tumor-associated macrophages in relation to tumor angiogenesis. We review the literature; many data
supporting this facet of tumor angiogenesis were derived from the breast cancer models. We scrutinize the large body of clinical
evidence exploring the link between the tumor-associated macrophages and breast tumor angiogenesis and discuss particularly
the methodology and limitations of incorporating such an assessment in histopathological examination.
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