Benzofuranyl Esters: Synthesis, Crystal Structure Determination, Antimicrobial and Antioxidant Activities

C. S., Chidan Kumar and Li, Yee Then and Tze, Shyang Chia and Chandraju, Siddegowda and Win, Yip Foo and Sulaiman, Shaida Fariza and Hashim, Nurul Shafiqah and Kheng, Leong Ooi and Ching, Kheng Quah and Fun, Hoong Kun (2015) Benzofuranyl Esters: Synthesis, Crystal Structure Determination, Antimicrobial and Antioxidant Activities. Molecules, 20 (9). pp. 16566-16581. ISSN 1420-3049

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A series of five new 2‐(1‐benzofuran‐2‐yl)‐2‐oxoethyl 4-(un/substituted)benzoates 4(a–e), with the general formula of C8H5O(C=O)CH2O(C=O)C6H4X, X = H, Cl, CH3, OCH3 or NO2, was synthesized in high purity and good yield under mild conditions. The synthesized products 4(a–e) were characterized by FTIR, 1H-, 13C- and 1H-13C HMQC NMR spectroscopic analysis and their 3D structures were confirmed by single-crystal X-ray diffraction studies. These compounds were screened for their antimicrobial and antioxidant activities. The tested compounds showed antimicrobial ability in the order of 4b < 4a < 4c < 4d < 4e and the highest potency with minimum inhibition concentration (MIC) value of 125 μg/mL was observed for 4e. The results of antioxidant activities revealed the highest activity for compound 4e (32.62% ± 1.34%) in diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, 4d (31.01% ± 4.35%) in ferric reducing antioxidant power (FRAP) assay and 4a (27.11% ± 1.06%) in metal chelating (MC) activity.

Item Type: Article
Subjects: Q Science > QC Physics > QC1-999 Physics
Q Science > QH Natural history > QH1 Natural history (General - Including nature conservation, geographical distribution)
Divisions: Pusat Pengajian Sains Fizik (School of Physics) > Article
Pusat Pengajian Sains Kajihayat (School of Biological Sciences) > Article
Depositing User: Mr Noorazilan Noordin
Date Deposited: 16 Jan 2018 07:10
Last Modified: 16 Jan 2018 07:10

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