Antituberculosis: Synthesis and Antimycobacterial Activity of Novel Benzimidazole Derivatives

Yeong, Keng Yoon and Ali, Mohamed Ashraf and Tan, Soo Choon and Ismail, Rusli and Ang, Chee Wei and Kumar, Raju Suresh and Osman, Hasnah and Beevi, Farzana (2013) Antituberculosis: Synthesis and Antimycobacterial Activity of Novel Benzimidazole Derivatives. BioMed Research International, 2013 (926309). pp. 1-6. ISSN 2314-6133

[img]
Preview
PDF
Download (1MB) | Preview

Abstract

A total of seven novel benzimidazoles were synthesized by a 4-step reaction starting from 4-fluoro-3-nitrobenzoic acid under relatively mild reaction conditions.The synthesized compounds were screened for their antimycobacterial activity against M. tuberculosis H37Rv (MTB-H37Rv) and INH-resistant M. tuberculosis (INHR-MTB) strains using agar dilution method. Three of them displayed good activity with MIC of less than 0.2

Item Type: Article
Subjects: Q Science > QD Chemistry > QD1-999 Chemistry
R Medicine > R Medicine (General) > R735-854 Medical education. Medical schools. Research
Divisions: Pusat Pengajian Sains Kimia (School of Chemistry) > Article
Zoom Profil Pakar (Expert Profile) > Professor Dato' Dr. Hasnah Osman (Chemical Sciences)
Depositing User: Mr Noorazilan Noordin
Date Deposited: 11 Jan 2018 06:29
Last Modified: 11 Jan 2018 06:29
URI: http://eprints.usm.my/id/eprint/38344

Actions (login required)

View Item View Item
Share