Nik Man, Nik Muhd Khuzaimi and Hassan, Rosline and Cheng, Yong Ang and Abdullah, Abu Dzarr Ganesh and Mohd Radzi, Muhammad Amiro Rasheeq and Sulaiman, Siti Amrah
(2015)
Antileukemic Effect of Tualang Honey on Acute and Chronic Leukemia Cell Lines.
BioMed Research International, 2015 (307094).
pp. 1-7.
ISSN 2314-6133
Abstract
Complementarymedicine using natural product as antitumor is on the rise.Much research has been performed on Tualang Honey
and it was shown to have therapeutic potential in wound healing, and antimicrobial activity and be antiproliferative against several
cancer models such as human osteosarcoma (HOS), human breast (MCF-7 and MDA-MB-231), and cervical (HeLa) cancer cell
lines. To date, there was limited study on antileukemic properties of Tualang (Koompassia excelsa) Honey. The aim of this study
was to evaluate the antileukemic effect of Tualang Honey on acute and chronic leukemia cell lines. Leukemia cell lines (K562
and MV4-11) and human mononuclear cell isolated from peripheral blood were grown in RPM1 1640 culture medium. The cells
were incubated with increasing concentrations of Tualang Honey. After incubation, the evaluation of viability and apoptosis was
performed. The morphological changes of leukemia cells were the presence of cytoplasmic blebs followed by apoptotic bodies and
round shape of cells. IC50 against K562 and MV4-11 was determined. Tualang Honey gave 53.9% and 50.6% apoptosis activity on
K562 and MV4-11, respectively, while on human mononuclear cell it was 37.4%. Tualang Honey has the apoptosis-inducing ability
for acute and chronic myeloid leukemia (K562 and MV4-11) cell lines.
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