An Expedient Synthesis, Acetylcholinesterase Inhibitory Activity, and Molecular Modeling Study of Highly Functionalized Hexahydro-1,6-naphthyridines

Almansour, Abdulrahman I. and Kumar, Raju Suresh and Arumugam, Natarajan and Basiri, Alireza and Kia, Yalda and Ali, Mohamed Ashraf (2015) An Expedient Synthesis, Acetylcholinesterase Inhibitory Activity, and Molecular Modeling Study of Highly Functionalized Hexahydro-1,6-naphthyridines. BioMed Research International, 2015 (965987). pp. 1-9. ISSN 2314-6133

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Abstract

A series of hexahydro-1,6-naphthyridines were synthesized in good yields by the reaction of 3,5-bis[(E)-arylmethylidene] tetrahydro-4(1H)-pyridinones with cyanoacetamide in the presence of sodium ethoxide under simple mixing at ambient temperature for 6–10 minutes and were assayed for their acetylcholinesterase (AChE) inhibitory activity using colorimetric Ellman’s method. Compound 4e with methoxy substituent at ortho-position of the phenyl rings displayed the maximum inhibitory activity with IC50 value of 2.12

Item Type:	Article
Subjects:	Q Science > QD Chemistry > QD1-999 Chemistry R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions:	Pusat Pengajian Sains Farmasi (School of Pharmacy) > Article Pusat Pengajian Sains Kimia (School of Chemistry) > Article
Depositing User:	Mr Noorazilan Noordin
Date Deposited:	09 Jan 2018 04:17
Last Modified:	09 Jan 2018 04:17
URI:	http://eprints.usm.my/id/eprint/38309

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