Lipopolysaccharide-Induced Memory Impairment in Rats: a Model of Alzheimer’s Disease

R., Zakaria and W. M. H., Wan Yaacob and Z., Othman and I. , Long and A. H. , Ahmad and B. , Al-Rahbi (2017) Lipopolysaccharide-Induced Memory Impairment in Rats: a Model of Alzheimer’s Disease. Physiological research, 66 (4). pp. 553-565. ISSN 0862-8408

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Abstract

Alzheimer’s disease (AD) is a primary cause of dementia in the middle-aged and elderly worldwide. Animal models for AD are widely used to study the disease mechanisms as well as to test potential therapeutic agents for disease modification. Among the non-genetically manipulated neuroinflammation models for AD, lipopolysaccharide (LPS)-induced animal model is commonly used. This review paper aims to discuss the possible factors that influence rats’ response following LPS injection. Factors such as dose of LPS, route of administration, nature and duration of exposure as well as age and gender of animal used should be taken into account when designing a study using LPS-induced memory impairment as model for AD.

Item Type:	Article
Subjects:	R Medicine > RC Internal medicine > RC31-1245 Internal medicine
Divisions:	Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Kesihatan (School of Health Sciences) > Article Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Perubatan (School of Medical Sciences) > Article
Depositing User:	Administrator Automasi
Date Deposited:	27 Dec 2017 04:03
Last Modified:	27 Dec 2017 04:03
URI:	http://eprints.usm.my/id/eprint/38100

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