A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines

I. Almansour, Abdulrahman and Kumar, Raju Suresh and Arumugam, Natarajan and Basiri, Alireza and Kia, Yalda and Ali, Mohamed Ashraf and Farooq, Mehvish and Murugaiyah, Vikneswaran (2015) A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines. Molecules, 20 (2). pp. 2296-2309. ISSN 1420-3049

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Abstract

A series of novel dimethoxyindanone embedded spiropyrrolidines were synthesized in ionic liquid, [bmim]Br and were evaluated for their inhibitory activities towards cholinesterases. Among the spiropyrrolidines, compound 4f exhibited the most potent activity with an IC50 value of 1.57 μM against acethylcholinesterase (AChE). Molecular docking simulation for the most active compound was employed with the aim of disclosing its binding mechanism to the active site of AChE receptor.

Item Type:	Article
Subjects:	Q Science > QD Chemistry > QD1-999 Chemistry R Medicine > R Medicine (General) > R735-854 Medical education. Medical schools. Research R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions:	Institut Penyelidikan Perubatan Molekul (Institute for Research in Molecular Medicine INFORMM) > Article Pusat Pengajian Sains Farmasi (School of Pharmacy) > Article Pusat Pengajian Sains Kimia (School of Chemistry) > Article
Depositing User:	Mr Noorazilan Noordin
Date Deposited:	20 Dec 2017 04:34
Last Modified:	20 Dec 2017 04:34
URI:	http://eprints.usm.my/id/eprint/38014

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