Antiproliferative Efficacy of Zerumbone-Loaded Nanostructured Lipid Carrier in BALB/C Mice Model of Breast Cancer

Rahman, Heshu Sulaiman and Abdullah, Rasedee and Othman, Hemn Hassan and Jalal Ali, Othman and Abdul, Ahmad Bustamam and Abdul Samad, Nozlena and SM, Chartrand and Swee, Keong Yeap and Hossienpour, Mahnaz (2014) Antiproliferative Efficacy of Zerumbone-Loaded Nanostructured Lipid Carrier in BALB/C Mice Model of Breast Cancer. Malaysian Journal of Veterinary Research, 5 (Supt 1). pp. 176-177. ISSN 2180-3897

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Abstract

Recently, we showed that the antiproliferative effect of ZER-NLC on Jurkat cells is through the apoptotic intrinsic pathway via activation of caspase-3 and -9, release of cytochrome c (cyt-c) from mitochondria into cytosol, and subsequent cleavage of polyADP-ribose polymerase (PARP). However, there has been no available information of ZER-NLC affects murine breast cancer cells in vivo. Thus, In this study, in vivo effects of ZER-NLC on murine breast cancer 4T1 cells were investigated. Outcomes of histopathology, immunohistochemistry and TUNEL assays of BALB/c mice bearing breast cancer revealed that the number of cancer cells were significantly decreased in mammary gland tissues after four weeks of oral administration of various doses of ZER-NLC.

Item Type: Article
Subjects: R Medicine > RZ Other systems of medicine
Divisions: Zoom Profil Pakar (Expert Profile) > Nozlena Abdul Samad (Advanced Medical & Dental Institute)
Depositing User: Administrator Automasi
Date Deposited: 15 Nov 2017 05:09
Last Modified: 15 Nov 2017 05:09
URI: http://eprints.usm.my/id/eprint/37411

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