Comparison of Dexmedetomidine 50μg versus 100μg added to 0.5% Levobupivacaine in Supraclavicular Brachial Plexus Block (BPB) for Arteriovenous Fistula (AVF) Surgery

Chong, Soon Eu and Ahmad, Mohd Nikman and Hassan, Mohd Fakhzan and Mohammad Zaini, Rhendra Hardy and Wan Hassan, Wan Mohd Nazaruddin (2013) Comparison of Dexmedetomidine 50μg versus 100μg added to 0.5% Levobupivacaine in Supraclavicular Brachial Plexus Block (BPB) for Arteriovenous Fistula (AVF) Surgery. In: 12th Asian & Oceanic Society of Regional Anaesthesia & Pain Medicine Congress, Jun 19 - 22, 2013, Kuching, Sarawak, Malaysia.

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    Abstract

    Background: Dexmedetomidine is an alpha-2 agonist used as sedation in ICU and remote anaesthesia. Unlike Clonidine, its effect as additive in peripheral nerve block has not been widely researched upon. The aim of this study is to compare the efficacy and outcome of additive dexmedetomidine 50μg versus 100μg to levobupivacaine 0.5% in supraclavicular brachial plexus block in AVF surgery . Methodology: Forty six adult with chronic renal failure patients scheduled for AVF surgery were studied in prospective, randomized, single operator double blinded study design. The supraclavicular block was performed with the ultrasound and a nerve stimulator technique.Group A (dexmedetomidine 50μg added to 20 ml of levobupivacaine 0.5 % + 1ml of normal saline) versus Group B (dexmedetomidine 100μg added to 20 ml of levobupivacaine 0.5 %). The onset, duration of action, haemodynamic parameters changes, vascular diameter changes and sedative effects were recorded Result: The onset of sensory and block is faster in Group B (8.08 ± 1.38); (P <0.002-sensory) and motor (11.33 ± 1.52; P< 0.024). Duration of action of the block is longer in Group B (12.3 ± 1.01); (P < 0.001). Sedation effects present in both group, however it is not statistically significant. (P> 0.5) Both group have a stable haemodynamic profiles. Group B causes significant increased the artery (0.020 ± 0.0067); (P<0.02) and vein diameter (0.022 ± 0.0074); (P<0.001). Conclusion: Dexmedetomidine as an additive for supraclacvicular block in ESRF patient for AVF surgery causes faster onset, prolonged duration of anesthesia, increase the artery and vein diameter and produced sedation effect with stable haemodynamic parameters.

    Item Type: Conference or Workshop Item (Poster)
    Subjects: R Medicine > RD Surgery > RD520-599.5 Surgery by region, system, or organ
    Divisions: Institut Perubatan & Pergigian Termaju (Advanced Medical & Dental Institute) > Conference or Workshop Item
    Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Perubatan (School of Medical Sciences) > Conference or Workshop Item
    Zoom Profil Pakar (Expert Profile) > Dr. Chong Soon Eu (Advanced Medical & Dental Institute)
    Depositing User: Administrator Automasi
    Date Deposited: 02 Nov 2017 14:08
    Last Modified: 02 Nov 2017 14:09
    URI: http://eprints.usm.my/id/eprint/37314

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