Abdul Rahman, Suzanah and Ahmad, Nur Amalina and Abdul Samat, Nadia Hanis and Zahri, Syazana and Abdullah, Afif Raihan and Chan, Kit Lam (2017) The potential of standardized quassinoid-rich extract of Eurycoma longifolia in the regulation of the oestrous cycle of rats. Asian Pacific Journal of Tropical Biomedicine, 7 (1). pp. 27-31. ISSN 2221-1691
Full text not available from this repository.Abstract
Objective: To evaluate the effects of Eurycoma longifolia (E. longifolia) standardized extract on the oestrous cycle, levels of reproductive hormones and histology of the ovaries of Sprague-Dawley rats. Methods: Female rats were orally treated with E. longifolia standardized extract at the dose levels of 2.5, 5.0, 10.0, 25.0, 50.0 and 100.0 mg/kg of body weight over 5 days. Vaginal smears were monitored daily within the duration and after withdrawal of the treatment before being sacrificed. The body weights of the females were recorded before and after the 5 days treatment. At the end of the experiments, blood samples were collected for determination of testosterone, oestradiol and progesterone levels. Ovaries were removed, weighed and examined for histomorphological changes. Results: The administration of E. longifolia standardized extract did not significantly alter the oestrous cycle of the rats during the 5 days treatment and after withdrawal of the treatments. This was supported by normal testosterone, oestradiol and progesterone levels as well as normal morphology of the ovaries. Conclusions: The data obtained showed that E. longifolia standardized extract did not exhibit any toxic effect on reproductive activities of female rats suggesting potential use in the management of infertility.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica |
| Divisions: | Pusat Pengajian Sains Farmasi (School of Pharmacy) > Article |
| Depositing User: | Mr Noorazilan Noordin |
| Date Deposited: | 30 Oct 2017 04:11 |
| Last Modified: | 30 Oct 2017 04:11 |
| URI: | http://eprints.usm.my/id/eprint/37262 |
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