Oral Administration of Tualang and Manuka Honeys Modulates Breast Cancer Progression in Sprague-Dawley Rats Model

Ahmed, Sarfraz and Sulaiman, Siti Amrah and Othman, Nor Hayati (2017) Oral Administration of Tualang and Manuka Honeys Modulates Breast Cancer Progression in Sprague-Dawley Rats Model. Evidence-Based Complementary and Alternative Medicine, 2017 (590436). pp. 1-15. ISSN 1741-427X

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    Abstract

    Breast cancer has been recognized as the leading cause of death in women worldwide. Research has shown the importance of complementary and alternative therapies in cancer. In this study, we investigated the antitumoural therapeutic effects ofMalaysian Tualang honey (TH) and Australian/New Zealand Manuka honey (MH) against breast cancer in rats. Thirty syngeneic virgin female Sprague-Dawley (SD) rats were induced by the carcinogen 1-methyl-1-nitrosourea (MNU) 80mg/kg. The treatment started when first palpable tumour reached 10–12mm in size by dividing rats into following groups: Group 0 (negative control); Group 1 (positive control); and Groups 2 and 3 which received 1.0 g/kg body weight/day of TH and MH, respectively, for 120 days. The data demonstrate that cancer masses in TH and MH treated groups showed a lower median tumour size, weight, and multiplicity compared with the nontreated positive control (

    Item Type: Article
    Subjects: R Medicine > RB Pathology
    R Medicine > RM Therapeutics. Pharmacology
    Divisions: Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Perubatan (School of Medical Sciences) > Article
    Depositing User: Mr Noorazilan Noordin
    Date Deposited: 13 Oct 2017 10:31
    Last Modified: 13 Oct 2017 10:31
    URI: http://eprints.usm.my/id/eprint/37099

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