Melittin, a Potential Natural Toxin of Crude Bee Venom: Probable Future Arsenal in the Treatment of Diabetes Mellitus

Hossen, Md. Sakib and Siew, Hua Gan and Khalil, Md. Ibrahim (2017) Melittin, a Potential Natural Toxin of Crude Bee Venom: Probable Future Arsenal in the Treatment of Diabetes Mellitus. Journal of Chemistry, 2017 (403562). pp. 1-7. ISSN 2090-9063

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Abstract

Since diabetes mellitus (DM) is one of the most common and serious endocrine metabolic disorders, it is important to elucidate novel antidiabetic therapeutic agents from various sources, including natural products. Bee venom (BV) is a complex mixture of proteins, peptides, and low molecular components, and melittin is the main constituent. Melittin is a peptide consisting of 26 amino acids with the sequence GIGAVLKVLTTGLPALISWIKRKRQQ. It has several important biological effects and has a relatively low toxicity. Recent studies using animal models have confirmed that melittin has significant glucose and lipid lowering activities by acting on several mechanistic pathways. The main antidiabetic activity of melittin is increasing insulin secretion via depolarization of pancreatic

Item Type:	Article
Subjects:	R Medicine > R Medicine (General) > R5-130.5 General works
Divisions:	Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Perubatan (School of Medical Sciences) > Article
Depositing User:	Mr Noorazilan Noordin
Date Deposited:	11 Oct 2017 06:54
Last Modified:	11 Oct 2017 06:54
URI:	http://eprints.usm.my/id/eprint/37052

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