Interspecies In Vitro Evaluation of Stereoselective Protein Binding for 3,4-Methylenedioxymethamphetamine

Wan Aasim, Wan Raihana and Soo, Choon Tan and Siew, Hua Gan (2017) Interspecies In Vitro Evaluation of Stereoselective Protein Binding for 3,4-Methylenedioxymethamphetamine. Journal of Chemistry, 2017 (810372). pp. 1-7. ISSN 2090-9063

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Abstract

Abuse of 3,4-methylenedioxymethamphetamine (MDMA) is becomingmore common worldwide. To date, there is no information available on stereoselectivity of MDMA protein binding in humans, rats, and mice. Since stereoselectivity plays an important role in MDMA’s pharmacokinetics and pharmacodynamics, in this study we investigated its stereoselectivity in protein binding. The stereoselective protein binding of rac-MDMA was nvestigated using two different concentrations (20 and 200 ng/mL) in human plasma and mouse and rat sera using an ultrafiltration technique. No significant stereoselectivity in protein binding was observed in both human plasma and rat serum; however, a significant stereoselective binding (

Item Type:	Article
Subjects:	R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions:	Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Perubatan (School of Medical Sciences) > Article Pusat Pengajian Sains Farmasi (School of Pharmacy) > Article
Depositing User:	Mr Noorazilan Noordin
Date Deposited:	10 Oct 2017 06:11
Last Modified:	10 Oct 2017 06:11
URI:	http://eprints.usm.my/id/eprint/37014

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