In vitro antimetastatic activity of Agarwood (Aquilaria crassna) essential oils against pancreatic cancer cells

Sabbar Dahham, Saad and M. Tabana, Yasser and Ahmed Hassan, Loiy E. and Khadeer Ahamed, Mohamed B. and Abdul Majid, Aman Shah and Abdul Majid, Amin Malik Shah (2016) In vitro antimetastatic activity of Agarwood (Aquilaria crassna) essential oils against pancreatic cancer cells. Alexandria Journal of Medicine, 52 (2). pp. 141-150. ISSN 2090-5068

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Abstract

Background Pancreatic cancer is one of the most lethal malignant tumors which remains a rampant killer across the globe. Lack of early diagnosis and toxic drugs have failed to improve the survival rate of pancreatic cancer patients, thus new agents that are safe, available and effective are urgently needed. Objective The study aimed to investigate the efficacy of Agarwood essential oils in the inhibition of metastasis and induction of apoptosis in the pancreatic cell line (MIA PaCa-2). Methods Essential oils of Aquilaria crassna were obtained by hydrodistillation. Chemical characterization was analyzed using FTIR and GCMS. The effects of essential oils against three steps of metastases have been investigated, including cell proliferation, migration and clonogenicity. Hoechst and rhodamine assays confirmed the mechanism of pancreatic cancer cell death. Results The results showed that essential oils exhibited potent cytotoxic activity against MIA PaCa-2 cells with an IC50 (11

Item Type: Article
Subjects: R Medicine > RK Dentistry > RK1-715 Dentistry
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: Institut Perubatan & Pergigian Termaju (Advanced Medical & Dental Institute) > Article
Depositing User: Mr Noorazilan Noordin
Date Deposited: 10 Oct 2017 00:50
Last Modified: 10 Oct 2017 00:50
URI: http://eprints.usm.my/id/eprint/36984

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