A review of optic perineuritis

Tai , Evelyn Li Min and Tevaraj, Jessica Mani Penny and Thavaratnam, Lakana Kumar and Mohd Noor, Raja Azmir and Win Mar , Salmah and Wan Hitam, Wan Hazabbah (2017) A review of optic perineuritis. International Eye Science, 17 (2). pp. 213-216. ISSN 1672-5123

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    Optic perineuritis ( OPN ) refers to a spectrum of conditions involving pathologic inflammation of the optic nerve sheath. The classic triad of OPN consists of unilateral optic neuropathy associated with pain and/or disc oedema, but the condition often mimics other optic neuropathies, resulting in delayed diagnosis and suboptimal treatment. We performed a database search of Medline and Ovid in January 2016 for articles published in any language with the keywords ‘optic perineuritis蒺. Sixty articles were found, published from 1956 to 2015. Two reviewers (Tai ELM and Tevaraj JMP) performed an independent screening of abstracts. Articles of interest were subsequently examined. In this review, we highlight the salient features of OPN, with particular emphasis on the clinical differences between OPN and optic neuritis. Although the majority of cases of OPN are idiopathic, investigations are required to rule out specific infectious and inflammatory causes of secondary OPN. MRI is an invaluable component of the workup, as radiographic demonstration of peri - neural inflammation is diagnostic of OPN. Corticosteroid therapy results in dramatic and rapid reversal of the signs and symptoms, but prolonged therapy with slow tapering of oral corticosteroids may be necessary to reduce the risk of relapses.

    Item Type: Article
    Subjects: R Medicine > RE Ophthalmology
    Divisions: Hospital Universiti Sains Malaysia (University Hospital) > Article
    Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Kesihatan (School of Health Sciences) > Article
    Depositing User: Mr Noorazilan Noordin
    Date Deposited: 21 Sep 2017 11:15
    Last Modified: 27 Sep 2017 08:44
    URI: http://eprints.usm.my/id/eprint/36714

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