Association of melanocortin 4 receptor (MC4R) gene mutation, physical activity, and food intake between normal and overweight Malay children

Tan, Yee Lin (2013) Association of melanocortin 4 receptor (MC4R) gene mutation, physical activity, and food intake between normal and overweight Malay children. Masters thesis, Universiti Sains Malaysia.

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Abstract

Masalah berat badan berlebihan dan obesiti telah menjadi isu yang membimbangkan di seluruh dunia dan masalah ini terus meningkat. Ketidakseimbangan penggunaan tenaga optima di mana pengambilan tenaga melebihi penggunaan tenaga menyebabkan obesiti. Masalah obesiti boleh disebabkan oleh interaksi antara faktor genetik, tingkahlaku dan persekitaran. Mutasi MC4R merupakan mutasi yang paling lazim dikenali sebagai punca 'monogenic obesity' dalam manusia. Ia menjejaskan homeostasis tenaga dengan meningkatkan pengambilan makanan dan mengurangkan penggunaan tenaga. Adalah didapati bahawa mutasi 'melanocortin 4 receptor' (MC4R) N62S yang ditemui dalam kalangan kanak-kanak yang berasal dari Pakistan telah menjejaskan sebahagian fungsi reseptor dan hal tersebut mungkin menyebabkan obesiti. Overweight and obesity has become an alarming issue worldwide and the problem is on the rise. Obesity arises when there is energy imbalance where energy intake exceeding energy expenditure. It can be resulted from the interaction between genetic, behavioral and environmental factors. Melanocortin 4 receptor (MC4R) mutation is the most common known monogenic cause of human obesity that impairs energy homeostasis by increasing food intake and decreasing energy expenditure. MC4R mutation N62S which was found in children of Pakistani origin was found to partially impair the receptor function which might cause obesity.

Item Type: Thesis (Masters)
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Perubatan (School of Medical Sciences)
Depositing User: Mr Noorazilan Noordin
Date Deposited: 08 Sep 2017 04:12
Last Modified: 12 Apr 2019 05:26
URI: http://eprints.usm.my/id/eprint/36422

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