Rahman, Aiman Nadia Akmar
(2013)
A study of peroxisome proliferator activated receptor gamma (PPARy) gene variant in relation to physical activity and fat intake among primary school Malay children in Kota Bharu, Kelantan.
Masters thesis, Universiti Sains Malaysia.
Abstract
Mutasi pertukaran antara Proline kepada Alanin di kodon 12 gen Peroxisome Proliferator Activated Receptor Gamma (Pro12Ala PPARγ) adalah salah satu daripada faktor genetik utama yang menyumbang kepada tenaga yang berlebihan dan mengakibatkan obesiti. Oleh itu, antara objektif kajian ini adalah untuk menentukan hubungkait antara variasi Pro12Ala pada gen PPARγ dan indeks jisim badan dalam kalangan kanak-kanak Melayu, menentukan perbezaan aktiviti fizikal antara subjek yang mempunyai mutasi gen dan tidak mempunyai mutasi Pro12Ala pada gen PPARγ dan menentukan perbezaan pengambilan lemak antara subjek yang mempunyai mutasi gen dan tidak mempunyai mutasi Pro12Ala pada gen PPARγ.
The missense mutation of Proline to Alanine at codon 12 (Pro12Ala) of Peroxisome Proliferator Activated Receptor Gamma (PPARγ) is one of the most critical genetic factors predisposing to positive energy balance that may lead to development of obesity. Hence, the objectives of this study are to determine the association between Pro12Ala variant in the PPARγ gene and body mass indexs (BMI) status of Malay children, to determine the differences of physical activity between subjects with and without Pro12Ala variant in the PPARγ gene and to determine the differences of fat intake between subjects with and without Pro12Ala variant in the PPARγ gene.
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