Identification Of Potential Toxoplasma Gondii cDNA Phage Clones And Production Of The Corresponding Recombinant Proteins In The Development Of IgG Avidity Assay For Serodiagnosis Of Toxoplasmosis

Teh, Ai Ying (2016) Identification Of Potential Toxoplasma Gondii cDNA Phage Clones And Production Of The Corresponding Recombinant Proteins In The Development Of IgG Avidity Assay For Serodiagnosis Of Toxoplasmosis. PhD thesis, Universiti Sains Malaysia.

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    Abstract

    Toksoplasmosis merupakan jangkitan berleluasa di seluruh dunia yang disebabkan oleh Toxoplasma gondii. Jangkitan akut (primer) di dalam kalangan wanita hamil boleh menyebabkan toksoplasmosis kongenital yang mengakibatkan kecacatan neonatal, kerosakan saraf dan mata fetus, atau kematian janin. Oleh sebab itu, penilaian peringkat toksoplasmosis (kronik atau akut) di dalam kalangan wanita hamil adalah penting untuk pengurusan pesakit yang baik. Ujian serologi kekal sebagai pendekatan yang paling biasa untuk diagnosis makmal dan juga penilaian peringkat jangkitan bagi penyakit Toxoplasma. Pengunaan kaedah IgG aviditi telah dibuktikan berguna dalam perbezaan jangkitan toksoplasmosis akut dan kronik. Aviditi IgG adalah rendah pada awal jangkitan dan meningkat secara beransur-ansur dari masa ke masa. Aviditi IgG yang tinggi mengesahkan jangkitan kronik, manakala aviditi IgG yang rendah menunjukkan kemungkinan jangkitan yang baru. Toxoplasmosis is a worldwide infection caused by Toxoplasma gondii. Acute (primary) infection in pregnant women can lead to congenital toxoplasmosis which causes neonatal malformation, neurological damage, eye lesions or fetal death. Therefore, assessment of the stage (chronic or acute) of toxoplasmosis in pregnant women is crucial for appropriate patient management. Serodiagnosis remains the most common approach for laboratory diagnosis of Toxoplasma infection as well as to assess the stage of the infection. Determination of IgG avidity has been proven to be useful in differentiating acute from chronic Toxoplasma infection. The IgG avidity is low at the beginning of the infection and gradually increases over time. High IgG avidity confirms chronic infection while low IgG avidity indicates a probable recent infection.

    Item Type: Thesis (PhD)
    Subjects: R Medicine > R Medicine (General) > R735-854 Medical education. Medical schools. Research
    Divisions: Institut Penyelidikan Perubatan Molekul (Institute for Research in Molecular Medicine INFORMM) > Thesis
    Depositing User: Mr Noorazilan Noordin
    Date Deposited: 07 Mar 2017 15:44
    Last Modified: 05 Apr 2017 14:12
    URI: http://eprints.usm.my/id/eprint/32318

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