Formulation Of Liposomes As A Drug Carrier For Buparvaquone

Narianan, Shailaja (2016) Formulation Of Liposomes As A Drug Carrier For Buparvaquone. Masters thesis, Universiti Sains Malaysia.

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    Abstract

    Kajian ini merangkumi penyediaan liposom sebagai pembawa drug buparvaquone yang merupakan ubat bagi rawatan penyakit leishmaniasis. Kajian awal bertumpu untuk menggantikan penggunaan klorofom dengan etanol sebagai pelarut lipid. Keputusan yang diperoleh menunjukkan liposom boleh dilarutkan dalam etanol dan klorofom boleh dikecualikan dari formulasi. Liposom tanpa drug disediakan melalui dua kaedah berbeza iaitu kaedah tradisional Bangham dan juga kaedah suntikan etanol. Kajian awal juga dijalankan bagi mengenalpasti factor-faktor yang mempengaruhi saiz dan polidispersiti liposom yang dihasilkan. Liposom juga diuji dengan menambah kolesterol dan alpha-tocopherol sebagai penstabil partikel liposom. Kajian menunjukkan liposom kaedah suntikan etanol lebih stabil berbanding liposom kaedah tradisional Bangham. Liposom yang dihasilkan menggunakan kaedah tradisional Bangham dikecualikan bagi ujian pelepasan dan pemerangkapan BPQ disebabkan ujian fizikokimia menunjukkan ia tidak stabil dalam jangka masa panjang. This study was carried out to encapsulate the drug buparvaquone (BPQ) and to study its physiochemical properties and along with its in vitro release study. Initial studies focused on elimination of chloroform as lipid solvent and its substitution with ethanol. Result obtained showed that chloroform can be substituted with ethanol. Two different fabrication methods were used to produce liposomes: 1) the classic Bangham method and 2) ethanol injection method. Preliminary study was conducted to study the parameters that affect the particle size and polydispersity index (PDI). Liposomes were formulated with the addition of stabilizers, cholesterol and alpha-tocopherol. The liposomes were characterized based on physicochemical characteristics to record their effects on size and polydispersity.

    Item Type: Thesis (Masters)
    Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
    Divisions: Pusat Pengajian Sains Farmasi (School of Pharmacy) > Thesis
    Depositing User: Mr Noorazilan Noordin
    Date Deposited: 24 Jan 2017 14:12
    Last Modified: 22 Mar 2017 09:59
    URI: http://eprints.usm.my/id/eprint/31783

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