The Effects Of Angiotensin Iconverting Enzyme (Ace) I/D And Alphaactinin- 3 (Actn3) R/X Gene Polymorphisms On Human Physical Performance And Health Within Malaysian Population

Ahmad Yusof @ Hanafi, Hazwani (2016) The Effects Of Angiotensin Iconverting Enzyme (Ace) I/D And Alphaactinin- 3 (Actn3) R/X Gene Polymorphisms On Human Physical Performance And Health Within Malaysian Population. PhD thesis, Universiti Sains Malaysia.

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    Abstract

    Perbezaan data set populasi dalam sorotan kajian semasa dengan laporan terhad di kalangan sampel Asia, di tambah pula dengan penemuan yang tidak konsisten di kalangan kumpulan etnik yang berbeza, serta kekurangan maklumat bagi penglibatan polimorfisme gen ACE I/D dan ACTN3 R/X dalam adaptasi latihan telah menghadkan keupayaan penyelidik untuk membuat kesimpulan yang bermakna yang berkaitan dengan kesan-kesan polimorfisme ini ke atas prestasi fizikal dan kesihatan manusia. Oleh itu, penyelidikan kedoktoran ini melaksanakan tiga siri kajian untuk mengkaji kesan polimorfisme gen ACE I/D dan ACTN3 R/X ke atas prestasi fizikal dan kesihatan manusia dalam populasi Malaysia. Dalam kajian pertama, sampel DNA telah diambil melalui sel bukal daripada 180 orang Asia dari Malaysia (70 lelaki, 110 perempuan) berumur 20.4 ± 1.6 tahun, dan 180 orang Kaukasia dari Australia (62 lelaki, 118 perempuan) berumur 23.3 ± 3.6 tahun. Dalam kajian kedua, sampel DNA telah diambil daripada 180 atlet terlatih Malaysia (148 lelaki, 32 perempuan) berumur 20.5 ± 1.9 tahun, 180 kawalan sedentari Malaysia, dan 33 atlet berkala Australia (semua lelaki) berumur 20.7 ± 4.0 tahun. A disparity population data set in the current literature with limited reports among Asian samples, coupled with the inconsistent findings among different ethnic groups, and lack of information for the involvement of angiotensin I-converting enzyme (ACE) I/D and alpha-actinin-3 (ACTN3) R/X gene polymorphisms in training adaptation have limited the ability of researchers to draw meaningful conclusions pertaining to the effects of these polymorphisms on human physical performance and health. Therefore, this doctoral research implemented three series of studies to examine the effects of ACE I/D and ACTN3 R/X gene polymorphisms on human physical performance and health within the Malaysian population. In the first study, DNA samples were retrieved via buccal cell from 180 Asians from Malaysia (70 males, 110 females) aged 20.4 ± 1.6 years, and 180 Caucasians from Australia (62 males, 118 females) aged 23.3 ± 3.6 years. In the second study, DNA samples were retrieved from 180 well-trained Malaysian athletes (148 males, 32 females) aged 20.5 ± 1.9 years, 180 Malaysian sedentary controls, and 33 intermittent Australian athletes (all males) aged 20.7 ± 4.0 years.

    Item Type: Thesis (PhD)
    Subjects: R Medicine > RK Dentistry > RK1-715 Dentistry
    Divisions: Institut Perubatan & Pergigian Termaju (Advanced Medical & Dental Institute) > Thesis
    Zoom Profil Pakar (Expert Profile) > Dr. Hazwani Ahmad Yusof@Hanafi (Advanced Medical & Dental Institute)
    Depositing User: Mr Noorazilan Noordin
    Date Deposited: 24 Jan 2017 09:38
    Last Modified: 08 Nov 2017 11:00
    URI: http://eprints.usm.my/id/eprint/31771

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