Interaction Studies Between Truncated Hpv16/18 E7 Oncoprotein With Ctcf/yb-1 Transcription Factors Complex

A. Wahab, Fatin Athirah (2016) Interaction Studies Between Truncated Hpv16/18 E7 Oncoprotein With Ctcf/yb-1 Transcription Factors Complex. Masters thesis, Universiti Sains Malaysia.

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    Abstract

    Human papillomavirus (HPV) adalah agen etiologi kanser serviks dimana HPV16 dan HPV18 tergolong dalam kumpulan HPV berisiko tinggi. Kajian terdahulu mendedahkan interaksi antara onkoprotin HPV16/18 E7 dengan kompleks faktor transkripsi CTCF/Yb-1. Interaksi ini menyebabkan ekspresi c-myc meningkat dengan ketara yang membawa kepada percambahan sel. Human Papillomavirus (HPV) is the aetiology agent of cervical cancer where HPV16 and HPV18 are the high-risk group of HPV. Previous study had revealed the interaction between HPV16/18 E7 oncoprotein with CTCF/Yb-1 transcription factors complex. This interaction resulted in marked enhancement of c-myc expression that leads cell proliferation.

    Item Type: Thesis (Masters)
    Subjects: R Medicine > R Medicine (General) > R735-854 Medical education. Medical schools. Research
    Divisions: Institut Penyelidikan Perubatan Molekul (Institute for Research in Molecular Medicine INFORMM) > Thesis
    Depositing User: Mr Firdaus Mohamad
    Date Deposited: 13 Jan 2017 15:57
    Last Modified: 05 Apr 2017 14:12
    URI: http://eprints.usm.my/id/eprint/31580

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