Design, Synthesis and Molecular Docking Studies of Some Novel Spiro Derivatives By 1,3-Cycloaddition Reaction

Hasmaruddin, Nurul Syazana and Osman , Hasnah and Mohamed Yusoff, Nadia and Ali, Mohamed Ashraf Ali and Hassan, Mohd. Zaheen (2016) Design, Synthesis and Molecular Docking Studies of Some Novel Spiro Derivatives By 1,3-Cycloaddition Reaction. In: International Conference on Natural Products 2016 (ICNP 2016) : Meeting The Needs of a Changing World Through Natural Products Biodiscover, 15 - 16th March 2016, Kuala Terengganu, Malaysia .

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    Abstract

    Synthesis of polycyclic compounds having spiro nucleus has attracted the attention of synthetic organic chemists because of their highly pronounced biological activities such as antiviral, antimicrobial etc. Therefore, the development of new, rapid, and clean synthetic routes of such compounds is of great importance to both medicinal and synthetic chemists. The 1,3-dipolarcycloaddition reactions are proved to be an efficient method for regio and stereo selective synthesis of structurally complex spiro heterocycles from relatively simple precursors. Molecular docking provides a consistent and more precise picture of the interaction of biologically active molecules at the receptor level thereby facilitating the designing of novel therapeutic agents. Therefore, potency of the spiro compounds (4i) was evaluated preliminary through the molecular docking studies. Later substitutions were made in the reference molecule to get the potent compounds.

    Item Type: Conference or Workshop Item (Poster)
    Uncontrolled Keywords: Spiro derivatives, Indanone, Molecular docking.
    Subjects: Q Science > QD Chemistry > QD1-999 Chemistry
    Q Science > QD Chemistry > QD241-441 Organic chemistry
    Divisions: Pusat Pengajian Sains Kimia (School of Chemistry)
    Depositing User: Administrator Automasi
    Date Deposited: 23 Dec 2016 17:21
    Last Modified: 23 Dec 2016 17:23
    URI: http://eprints.usm.my/id/eprint/31335

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